CAMARADES Systematic Review Wiki
1
Welcome
2
Preclinical Systematic Reviews
2.1
What is a systematic review?
2.2
What is a meta-analysis?
2.3
Clinical & preclinical reviews
2.4
Why perform preclinical SRs?
3
Systematic Reviews & 3Rs
4
Before You Start
4.1
Is it necessary?
4.2
Has it been done before?
4.3
Is one already in progress?
4.4
Build your systematic review team
4.4.1
Collborating with your team
5
Research Question
5.1
Stakeholders
5.2
Preclinical examples
6
Protocol
6.1
What is a protocol and why have one?
6.2
Protocol templates
6.3
Register your protocol
6.3.1
Your protocol & 3Rs
7
Systematic Search
7.1
Selecting databases
7.1.1
PubMed
7.1.2
Embase
7.1.3
Web of Science
7.1.4
Other sources & grey literature
7.2
Search strategy development
7.2.1
Step 1: Find keywords and synonyms for each element
7.2.2
Step 2: Index/subject terms (database-specific)
7.2.3
Step 3: Combining search terms using Boolean operators
7.2.4
Precision & sensitivity
7.2.5
Tips & tricks
7.3
Combine search results
7.3.1
Does the import order matter? YES!
7.4
Deduplication
7.5
Searching tools
7.6
Find & retrieve full texts
7.6.1
Tips & tricks for full text retrieval
8
Study Selection
8.1
Inclusion & exclusion criteria
8.2
Apply your criteria
8.3
Tools for screening
9
Data Extraction
9.1
Study characteristics
9.2
Quantitative data
9.3
Data extraction software
10
Quality Assessment
10.1
Why assess study quality?
10.2
Reporting quality
10.3
Risk of bias / methodological quality
10.4
RoB assessment to inform analysis
11
Meta-Analysis
11.1
What is Meta-Analysis?
11.2
Why perform Meta-Analysis?
11.3
Meta-Analysis Tools
11.4
Step 1. Calculate effect size
11.4.1
Continuous
11.4.2
Dichotomous Outcomes
11.4.3
Median
11.4.4
True number of Controls
11.5
Step 2. Combine effect sizes
11.5.1
Fixed Effects Model
11.5.2
Random Effects Model
11.6
Step 3. Investigate heterogeneity
11.7
Step 4. Reporting biases
11.8
Step 5. Interpret the results
12
Tools for Systematic Review
13
Publication
13.1
Good reporting
14
Resources & Links
14.1
Systematic Review Facility - CAMARADES
14.2
Templates & Guides
14.3
GRADE Approach
15
Workshops & Tutorials
15.1
Workshops
15.2
Meta-Analysis Tutorial
16
About
16.0.1
To cite the tool
16.0.2
Our Team
Contact Us Here
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Preclinical Systematic Review Wiki
Section 14
Resources & Links
14.1
Systematic Review Facility - CAMARADES
SyRF
SyRF Help Guide
14.2
Templates & Guides
SYRCLE Protocol - Template & Paper
Borenstein et al., 2009. Introduction to Meta-Analysis
Vesterinen et al, 2014. “Meta-analysis of data from animal studies: a practical guide.” Journal of neuroscience methods
Cochrane Handbook
14.3
GRADE Approach
Hooijmans et al., 2018. Preclinical GRADE Approach